Hepatitis B Virus Genotypes and Precore and Core Mutants in Brazilian Patients

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Hepatitis B virus genotypes and precore and core mutants in Brazilian patients.

A method for genotyping hepatitis B virus by partial HBsAg gene sequencing with primers common to all known genotypes was developed. Mutations related to anti-HBs resistance are also detected with this method. Samples from 103 Brazilian patients were analyzed. Precore and core region of these viruses were also sequenced in 101 patients. Genotypes A, B, C, D, and F were found with frequencies of...

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BACKGROUND Mutations in basal core promoter (BCP) and precore regions of hepatitis B virus (HBV) are associated with course and treatment outcomes of chronic HBV infection. While BCP and precore mutation analysis have been carried out in adult patients between different genotypes, this analysis has rarely been performed for chronically infected children. OBJECTIVES The aim of this study was t...

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mutations of basal core promoter and precore regions in hepatitis b virus genotypes b and c

conclusions the mutation ratio difference between genotypes b and c in children was higher than that of adults and several combined mutations were exclusively detected in children with chronic hbv genotype c infection associated with higher viral load. objectives the aim of this study was to assess the mutation profiles of bcp and precore regions in different hbv genotypes in chronically infect...

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ژورنال

عنوان ژورنال: Journal of Clinical Microbiology

سال: 2004

ISSN: 0095-1137,1098-660X

DOI: 10.1128/jcm.42.6.2455-2460.2004